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Cover Story

Sharing Data to Solve the Riddle of Autism

Worldwide, at least one in 100 people have autism spectrum disorder. In the United States, the Centers for Disease Control and Prevention put the number at one in 68. Despite the high prevalence and increased awareness of autism in recent years, the underlying mechanisms still remain unclarified.

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Emotional Matters

We speak to Affectiva cofounder and CEO Rana el Kaliouby about the opportunities that these products provide in areas such as mental health, mood tracking, and telemedicine as well as the challenges associated with achieving business success.

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Feeling No Pain

As a growing epidemic of opioid abuse in the United States can attest, pain, and how to treat it effectively and without serious side effects, is one of the foremost challenges in medicine today.

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The Foundry: Scaling Up Biological Design

Above: Depicted, from left to right: Chris Voigt, Ben Gordon, Rob Nicol. Photo by Lillie Paquette / MIT School of Engineering.
Living organisms are amazing feats of engineering: By following instructions encoded entirely in DNA, living systems can sense and respond to their environment, build intricate structures

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Putting a Number on Pain

Will new technologies substantially change the way subjective complaints are measured in clinical trials, and, if so, by how much? Depending on the expert consulted, the answer ranges from a little to a lot.